Inflammatory bowel disease: new therapies from antisense oligonucleotides
نویسندگان
چکیده
منابع مشابه
New and emerging therapies for inflammatory bowel disease.
SD One of the major discoveries in Crohn’s disease over the past few years has been the realization that the innate immune system plays a key role in the disease mechanism. Following an initial defect in the innate immune system, there is overreaction of the adaptive immune system, which leads to the classical inflammatory response that has been described in these patients. Ulcerative colitis h...
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BACKGROUND AND AIMS Medical therapy of inflammatory bowel disease (IBD) is becoming more complex, given the increasing choice of drugs to treat Crohn's disease (CD) and ulcerative colitis (UC). We aimed to summarize the current guidelines for first-line treatments in IBD. METHODS An extensive literature search with focus on the guidelines of the European Crohn's and Colitis Organisation for t...
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Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
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Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable potential. RASONs overcome previous obstacles that have impeded the development of antisense therapeutics targeting diseases in other organ systems. RASONs are delivered directly to the target tissue via inhalation; their uptake s...
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Many genetic neurological diseases result from the dysfunction of single proteins. Genetic therapies aim to modify these disease-associated proteins by targeting the RNA and DNA precursors. This review provides a brief overview of the main types of genetic therapies, with a focus on antisense oligonucleotides (ASOs) and RNA interference (RNAi). We use examples of new genetic therapies for spina...
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ژورنال
عنوان ژورنال: Annals of Medicine
سال: 2018
ISSN: 0785-3890,1365-2060
DOI: 10.1080/07853890.2018.1490025